Cent Eur J Nurs Midw 2024, 15(1):1077-1087 | DOI: 10.15452/cejnm.2024.15.0005

Cognitive impairment and emotional disturbances in young ischaemic stroke patients – scoping review

Lenka ©tureková1, Elena Gurková1, Daniel ©aňák2
1 Department of Nursing, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czech Republic
2 Comprehensive Stroke Center, Department of Neurology, Palacký University Medical School and Hospital, Olomouc, Czech Republic

Aim: To describe current scientific knowledge on cognitive impairment and emotional disturbances (anxiety and depression) in younger adult patients after ischemic stroke.

Design: A scoping review.

Methods: For the search, the following scientific databases were utilized: Web of Science, MEDLINE (Ovid), ScienceDirect (Elsevier), PsycInfo (EBSCO), Scopus (Elsevier), and ProQuest. Relevant studies were identified by searching publications from 2000 to July 2023.

Results: A total of eight studies were ultimately included in the review. Cognitive impairment occurred in a range between 39.4% and 40%. This encompassed various aspects of cognitive function, such as working memory, processing speed, global cognitive function, immediate and delayed memory, attention, and executive functioning. Depression had an incidence rate ranging from 10.8% to 16.8%. Several risk factors were associated with a higher likelihood of developing generalized anxiety. These included younger age, more depressive symptoms, lower education, unemployment, a history of depression, and alcohol use. In the context of depressive symptoms, a higher risk was linked to lower education and unemployment.

Conclusion:  The included studies highlighted the need to assess these issues not only at the time of patient discharge but, more importantly, during the stage of further recovery. This can contribute to the creation of tailored interventions for these individuals.

Keywords: anxiety, cognitive impairment, depression, ischemic stroke, young adult

Received: September 29, 2023; Revised: February 18, 2024; Accepted: February 19, 2024; Prepublished online: February 29, 2024; Published: March 6, 2024  Show citation

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©tureková L, Gurková E, ©aňák D. Cognitive impairment and emotional disturbances in young ischaemic stroke patients – scoping review. Central European Journal of Nursing and Midwifery. 2024;15(1):1077-1087. doi: 10.15452/cejnm.2024.15.0005.
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    References

    1. Ankolekar, S., Renton, C., Sare, G., Ellender, S., Sprigg, N., Wardlaw, J. M., Bath, P. M., & ENOS Trial Investigators. (2014). Relationship between poststroke cognition, baseline factors, and functional outcome: data from "efficacy of nitric oxide in stroke" trial. Journal of Stroke and Cerebrovascular Diseases, 23(7), 1821-1829. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.022 Go to original source... Go to PubMed...
    2. Ayerbe, L., Ayis, S. A., Crichton, S., Wolfe, C. D., & Rudd, A. G. (2014). Natural history, predictors and associated outcomes of anxiety up to 10 years after stroke: the South London Stroke Register. Age and Ageing, 43(4), 542-547. https://doi.org/10.1093/ageing/aft208 Go to original source... Go to PubMed...
    3. Barker-Collo, S., Feigin, V. L., Parag, V., Lawes, C. M., & Senior, H. (2010). Auckland Stroke Outcomes Study. Part 2: Cognition and functional outcomes 5 years poststroke.Neurology, 75(18), 1608-1616. https://doi.org/10.1212/WNL.0b013e3181fb44c8 Go to original source... Go to PubMed...
    4. Béjot, Y., Delpont, B., & Giroud, M. (2016). Rising stroke incidence in young adults: more epidemiological evidence, more questions to be answered. Journal of the American Heart Association, 5(5), e003661. https://doi.org/10.1161/JAHA.116.003661 Go to original source... Go to PubMed...
    5. Cao, M., Ferrari, M., Patella, R., Marra, C., & Rasura, M. (2007). Neuropsychological findings in young-adult stroke patients. Archives of Clinical Neuropsychology, 22(2), 133-142. https://doi.org/10.1016/j.acn.2006.09.005 Go to original source... Go to PubMed...
    6. Chun, H. Y., Whiteley, W. N., Dennis, M. S., Mead, G. E., & Carson, A. J. (2018). Anxiety after stroke: the importance of subtyping. Stroke, 49(3), 556-564. https://doi.org/10.1161/STROKEAHA.117.020078 Go to original source... Go to PubMed...
    7. Cumming, T. B., Blomstrand, C., Skoog, I., & Linden, T. (2016). The high prevalence of anxiety disorders after stroke. The American Journal of Geriatric Psychiatry, 24(2), 154-160. https://doi.org/10.1016/j.jagp.2015.06.003 Go to original source... Go to PubMed...
    8. de Bruijn, M. A., Synhaeve, N. E., van Rijsbergen, M. W., de Leeuw, F. E., Jansen, B. P., & de Kort, P. L. (2014). Long-term cognitive outcome of ischaemic stroke in young adults. Cerebrovascular diseases, 37(5), 376-381. https://doi.org/10.1159/000362592 Go to original source... Go to PubMed...
    9. Donnellan, C., Hickey, A., Hevey, D., & O'Neill, D. (2010). Effect of mood symptoms on recovery one year after stroke. International Journal of Geriatric Psychiatry, 25(12), 1288-1295. https://doi.org/10.1002/gps.2482 Go to original source... Go to PubMed...
    10. Edwards, J. D., Kapoor, A., Linkewich, E., & Swartz, R. H. (2018). Return to work after young stroke: a systematic review. International Journal of Stroke, 13(3), 243-256. https://doi.org/10.1177/1747493017743059 Go to original source... Go to PubMed...
    11. Hackett, M. L., Hill, K. M., Hewison, J., Anderson, C. S., House, A. O., Auckland Regional Community Stroke Study, & Stroke Outcomes Study Group. (2010). Stroke survivors who score below threshold on standard depression measures may still have negative cognitions of concern. Stroke, 41(3), 478-481. https://doi.org/10.1161/STROKEAHA.109.571729 Go to original source... Go to PubMed...
    12. Huang, Y., Yang, S., & Jia, J. (2015). Factors related to long-term post-stroke cognitive impairment in young adult ischemic stroke. Medical Science Monitor, 21, 654-660. https://doi.org/10.12659/MSM.892554 Go to original source... Go to PubMed...
    13. Kapoor, A., Lanctôt, K. L., Bayley, M., Kiss, A., Herrmann, N., Murray, B. J., & Swartz, R. H. (2017). "Good Outcome" isn't good enough: cognitive impairment, depressive symptoms, and social restrictions in physically recovered stroke patients. Stroke, 48(6), 1688-1690. https://doi.org/10.1161/STROKEAHA.117.016728 Go to original source... Go to PubMed...
    14. Kapoor, A., Si, K., Yu, A. Y. X., Lanctot, K. L., Herrmann, N., Murray, B. J., & Swartz, R. H. (2019). Younger age and depressive symptoms predict high risk of generalized anxiety after stroke and transient ischemic attack. Stroke, 50(9), 2359-2363. https://doi.org/10.1161/STROKEAHA.119.025464 Go to original source... Go to PubMed...
    15. Kauranen, T., Turunen, K., Laari, S., Mustanoja, S., Baumann, P., & Poutiainen, E. (2013). The severity of cognitive deficits predicts return to work after a first-ever ischaemic stroke. Journal of Neurology, Neurosurgery, And Psychiatry, 84(3), 316-321. https://doi.org/10.1136/jnnp-2012-302629 Go to original source... Go to PubMed...
    16. Kissela, B. M., Khoury, J. C., Alwell, K., Moomaw, C. J., Woo, D., Adeoye, O., Flaherty, M. L., Khatri, P., Ferioli, S., De Los Rios La Rosa, F., Broderick, J. P., & Kleindorfer, D. O. (2012). Age at stroke: temporal trends in stroke incidence in a large, biracial population. Neurology, 79(17), 1781-1787. https://doi.org/10.1212/WNL.0b013e318270401d Go to original source... Go to PubMed...
    17. Maaijwee, N. A., Rutten-Jacobs, L. C., Schaapsmeerders, P., van Dijk, E. J., & de Leeuw, F. E. (2014). Ischaemic stroke in young adults: risk factors and long-term consequences. Nature Reviews Neurology, 10(6), 315-325. https://doi.org/10.1038/nrneurol.2014.72 Go to original source... Go to PubMed...
    18. Maaijwee, N. A., Tendolkar, I., Rutten-Jacobs, L. C., Arntz, R. M., Schaapsmeerders, P., Dorresteijn, L. D., Schoonderwaldt, H. C., van Dijk, E. J., & de Leeuw, F. E. (2016). Long-term depressive symptoms and anxiety after transient ischaemic attack or ischaemic stroke in young adults. European Journal of Neurology, 23(8), 1262-1268. https://doi.org/10.1111/ene.13009 Go to original source... Go to PubMed...
    19. Mitchell, A. J., Sheth, B., Gill, J., Yadegarfar, M., Stubbs, B., Yadegarfar, M., & Meader, N. (2017). Prevalence and predictors of post-stroke mood disorders: a meta-analysis and meta-regression of depression, anxiety and adjustment disorder. General Hospital Psychiatry, 47, 48-60. https://doi.org/10.1016/j.genhosppsych.2017.04.001 Go to original source... Go to PubMed...
    20. Morris, J. H., van Wijck, F., Joice, S., & Donaghy, M. (2013). Predicting health related quality of life 6 months after stroke: the role of anxiety and upper limb dysfunction. Disability and Rehabilitation, 35(4), 291-299. https://doi.org/10.3109/09638288.2012.691942 Go to original source... Go to PubMed...
    21. Pendlebury, S. T., & Rothwell, P. M. (2009). Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. The Lancet Neurology, 8(11), 1006-1018. https://doi.org/10.1016/S1474-4422(09)70236-4 Go to original source... Go to PubMed...
    22. Pinter, D., Enzinger, C., Gattringer, T., Eppinger, S., Niederkorn, K., Horner, S., Fandler, S., Kneihsl, M., Krenn, K., Bachmaier, G., & Fazekas, F. (2019). Prevalence and short-term changes of cognitive dysfunction in young ischaemic stroke patients. European Journal of Neurology, 26(5), 727-732. https://doi.org/10.1111/ene.13879 Go to original source... Go to PubMed...
    23. Putaala, J. (2016). Ischemic stroke in the young: current perspectives on incidence, risk factors, and cardiovascular prognosis. European Stroke Journal, 1(1), 28-40. https://doi.org/10.1177/2396987316629860 Go to original source... Go to PubMed...
    24. Rafsten, L., Danielsson, A., & Sunnerhagen, K. S. (2018). Anxiety after stroke: a systematic review and meta-analysis. Journal of Rehabilitation Medicine, 50(9), 769-778. https://doi.org/10.2340/16501977-2384 Go to original source... Go to PubMed...
    25. Raju, R. S., Sarma, P. S., & Pandian, J. D. (2010). Psychosocial problems, quality of life, and functional independence among Indian stroke survivors. Stroke, 41(12), 2932-2937. https://doi.org/10.1161/STROKEAHA.110.596817 Go to original source... Go to PubMed...
    26. Rutten-Jacobs, L. C., Arntz, R. M., Maaijwee, N. A., Schoonderwaldt, H. C., Dorresteijn, L. D., van Dijk, E. J., & de Leeuw, F. E. (2013). Long-term mortality after stroke among adults aged 18 to 50 years. JAMA, 309(11), 1136-1144. https://doi.org/10.1001/jama.2013.842 Go to original source... Go to PubMed...
    27. Schaapsmeerders, P., Maaijwee, N. A., van Dijk, E. J., Rutten-Jacobs, L. C., Arntz, R. M., Schoonderwaldt, H. C., Dorresteijn, L. D., Kessels, R. P., & de Leeuw, F. E. (2013). Long-term cognitive impairment after first-ever ischemic stroke in young adults. Stroke, 44(6), 1621-1628. https://doi.org/10.1161/STROKEAHA.111.000792 Go to original source... Go to PubMed...
    28. Sienkiewicz-Jarosz, H., Milewska, D., Bochyńska, A., Chełmniak, A., Dworek, N., Kasprzyk, K., Gałecka, K., Szczepańska-Szarej, A., Chwojnicki, K., Zyluk, B., Słowik, A., & Ryglewicz, D. (2010). Predictors of depressive symptoms in patients with stroke - a three-month follow-up. Neurologia i Neurochirurgia Polska, 44(1), 13-20. https://doi.org/10.1016/s0028-3843(14)60402-3 Go to original source... Go to PubMed...
    29. Sturm, J. W., Donnan, G. A., Dewey, H. M., Macdonell, R. A., Gilligan, A. K., & Thrift, A. G. (2004). Determinants of handicap after stroke: the North East Melbourne Stroke Incidence Study (NEMESIS). Stroke, 35(3), 715-720. https://doi.org/10.1161/01.STR.0000117573.19022.66 Go to original source... Go to PubMed...
    30. Synhaeve, N. E., Schaapsmeerders, P., Arntz, R. M., Maaijwee, N. A., Rutten-Jacobs, L. C., Schoonderwaldt, H. C., Dorresteijn, L. D., de Kort, P. L., van Dijk, E. J., Kessels, R. P., & de Leeuw, F. E. (2015). Cognitive performance and poor long-term functional outcome after young stroke. Neurology, 85(9), 776-782. https://doi.org/10.1212/WNL.0000000000001882 Go to original source... Go to PubMed...
    31. Synhaeve, N. E., Arntz, R. M., van Alebeek, M. E., van Pamelen, J., Maaijwee, N. A., Rutten-Jacobs, L. C., Schoonderwaldt, H. C., de Kort, P. L., van Dijk, E. J., & de Leeuw, F. E. (2016). Women have a poorer very long-term functional outcome after stroke among adults aged 18-50 years: the FUTURE study. Journal of Neurology, 263(6), 1099-1105. https://doi.org/10.1007/s00415-016-8042-2 Go to original source... Go to PubMed...
    32. Tanislav, C., Kropp, P., Grittner, U., Holzhausen, M., Fazekas, F., Jungehülsing, G. J., Tatlisumak, T., von Sarnowski, B., Putaala, J., Huber, R., Thijs, V., Schmidt, R., Kaps, M., Enzinger, C., Dichgans, M., Norrving, B., & Rolfs, A. (2015). Clinically relevant depressive symptoms in young stroke patients - results of the sifap1 study. Neuroepidemiology, 44(1), 30-38. https://doi.org/10.1159/000371389 Go to original source... Go to PubMed...
    33. Turunen, K. E. A., Laari, S. P. K., Kauranen, T. V., Uimonen, J., Mustanoja, S., Tatlisumak, T., & Poutiainen, E. (2018). Domain-Specific cognitive recovery after first-ever stroke: a 2-year follow-up. Journal of the International Neuropsychological Society, 24(2), 117-127. https://doi.org/10.1017/S1355617717000728 Go to original source... Go to PubMed...
    34. Vandenbroucke, J. P., von Elm, E., Altman, D. G., Gøtzsche, P. C., Mulrow, C. D., Pocock, S. J., Poole, C., Schlesselman, J. J., Egger, M., & STROBE Initiative. (2014). Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. International Journal of Surgery, 12(12), 1500-1524. https://doi.org/10.1016/j.ijsu.2014.07.014 Go to original source... Go to PubMed...
    35. Waje-Andreassen, U., Thomassen, L., Jusufovic, M., Power, K. N., Eide, G. E., Vedeler, C. A., & Naess, H. (2013). Ischaemic stroke at a young age is a serious event - final results of a population-based long-term follow-up in Western Norway. European Journal of Neurology, 20(5), 818-823. https://doi.org/10.1111/ene.12073 Go to original source... Go to PubMed...
    36. Weterings, R. P., Kessels, R. P., de Leeuw, F. E., & Piai, V. (2023). Cognitive impairment after a stroke in young adults: a systematic review and meta-analysis. International Journal of Stroke, 18(8), 888-897. https://doi.org/10.1177/17474930231159267 Go to original source... Go to PubMed...
    37. World Health Organization (2020). The top 10 causes of death. WHO. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death

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