Cent Eur J Nurs Midw 2015, 6(2):237-244 | DOI: 10.15452/CEJNM.2015.06.0010

The effect of antihypertensive therapy on human sexuality

Bohdana Břegová1,*, Yvetta Vrublová2
1 Internal medicine, University Hospital Ostrava, Czech Republic
2 Department of Nursing and Midwifery, Faculty of Medicine, University of Ostrava, Czech Republic

Aim: The aim was to analyse the effect of antihypertensive therapy on incidence of sexual dysfunction in patients with arterial hypertension.

Design: a review study.

Methods: In the period from 2000 to 2015 we searched licensed and freely available electronic databases: CINAHL EBSCOhost, ProQuest, Pubmed and Medline for relevant recherches of Czech and foreign sources. We set the following criteria: a study of least 100 participants and a minimum six-month follow-up. We excluded experimental and vaguely defined studies. From a total of 123 searches, 45 articles met the criteria. A review includes a total of 15 studies, six studies with a control group of healthy individuals, two cohort studies, six randomized trials and one case study with a control group.

Results: The study analysis showed that beta-blockers and thiazide diuretics are the most detrimental in terms of incidence of sexual dysfunction. Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors have a neutral or beneficial effect.

Conclusion: The review article deals with the issue of patients' sexuality, focusing on the potentially negative effect of antihypertensive therapy on sexual function. Current scientific findings suggest that antihypertensive therapy increases the risk of occurence of sexual dysfunction. Professional literature is more dedicated to the incidence of male sexual dysfunction, especially erectile dysfunction, than with female sexual dysfunction.

Keywords: hypertension, antihypertensive therapy, sexual function, sexuality, sexual dysfunction

Received: February 9, 2015; Accepted: March 31, 2015; Published: September 30, 2015  Show citation

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Břegová B, Vrublová Y. The effect of antihypertensive therapy on human sexuality. Central European Journal of Nursing and Midwifery. 2015;6(2):237-244. doi: 10.15452/CEJNM.2015.06.0010.
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    References

    1. Bener A, Al-Ansari A, Al-Hamaq AO, Elbagi IE, Afifi M. Prevalence of erectile dysfunction among hypertensive and nonhypertensive Qatari men. Medicina (Kaunas). 2007;43(11):870-878. Go to original source... Go to PubMed...
    2. Berková M, Berka Z, Topinková E. Problematika arteriální hypertenze v otázkách a odpovědích. Geriatrie a gerontologie. 2014;3(1):5-11. (in Czech)
    3. Bultas J, Karetová D. Farmakoterapie erektilní dysfunkce - kde jsme a kam směřujeme. Kardiologická Revue - Interní Medicína. 2014;16(4):281-287. (in Czech)
    4. Conaglen HM, Conaglen JV. Drug - induced sexual dysfunction in men and women. Australian prescriber. 2013;36(2):42-46. Go to original source...
    5. Cuéllar de León AJ, Ruiz GV, Casmos GJC, Pérez HP, Brotons MB. Prevalence erectile dysfunction in patients with hypertension. Journal of Medicina Clinica (Barcelona). 2002;119(14):521-526. Go to original source... Go to PubMed...
    6. Doumas M, Tsiodras S, Tsakiris A, Douma S, Chounta A, Papadopoulos A, Kanellakopoulou K, Giamarellou H. Female sexual dysfuncion in essentials hypertension: a common problem being uncovered. Journal of Hypertension. 2006;24(12):2387-2392. Go to original source... Go to PubMed...
    7. Duncan LE, Lewis C, Jenkins P, Pearson T. Does hypertension and its pharmacotherapy affect the quality of sexual function in women? American Journal of Hypertension. 2000;13(6):640-647. Go to original source... Go to PubMed...
    8. Fogari R, Zoppi A, Poletti L, Marasi G, Mugellini A, Corradi L. Sexual activity in hypertensive men treated with valsartan or carvedilol: a crossover study. American Journal Hypertension. 2001;14(1):27-31. Go to original source... Go to PubMed...
    9. Fogari R, Preti P, Derosa G, Marasi G, Zoppi A, Rinaldi A, Mugellini A. Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and plasma testosterone in hypertensive men. The Europe Journal of Clinical Pharmacology. 2002;58(3):77-80. Go to original source... Go to PubMed...
    10. Fogari R, Preti P, Zoppi A, Corradi L, Pasotti C, Rinaldi A, Mugellini A. Effect of valsartan and atenolol on sexual behavior in hypertesive postmenopausal woman. American Journal Hypertension. 2004;17(1):77-81. Go to original source... Go to PubMed...
    11. Gladkij I et al. Management ve zdravotnictví. 1. vyd. Brno: Computer Press; 2003. (in Czech)
    12. Guirao Sánchez L, García-Giralda Ruiz L, Sandoval Martínez C, Mocciaro Loveccio A. Erectile dysfunction in primary care as possible marker of health status: associated factors and response to sildenafil. Atención Primaria. 2002;30(5):290- 296. Go to original source... Go to PubMed...
    13. Huang YP, Chen B, Ping P, Wang HX, Hu K, Yang H, Zhang T, Feng T, Jin Y, Han YF, Wang YX, Huang YR. Asexuality development among middle aged and older men. Plos One. 2014;9(3):e92794. Go to original source... Go to PubMed...
    14. Kütmec C, Yurtsever S. Effects of sexual function of essential hypertensions in women. European Journal of Cardivascular Nursing. 2011;10(1):56-63. Go to original source... Go to PubMed...
    15. Ma R, Yu J, Xu D, Yang L, Lin X, Li X, Chang P, Feng Z, Guo X, Bai F. The relationship between oxidative stress and sexual dysfunction in female patients with hypertension. Journal of Cardiology. 2011;152(1):S9. Go to original source...
    16. Manolis A, Doumas M. Sexual dysfunction: the ´prima ballerina´ of hypertension-related quality-of-life complication. Journal of Hypertension. 2008;26(11):2074-2084. Go to original source... Go to PubMed...
    17. Manolis A, Doumas M. Antihypertensive treatment and sexual dysfunction. Current Hypertension Research. 2012;14(4):285-292. Go to original source... Go to PubMed...
    18. Martelli V, Valisella S, Moscatiello S, Matteucci C, Lantadilla C, Costantino A, Pelusi G, Marchesini G, Meriggiola MC. Prevalence of sexual dysfunction among postmenopausal women with and without metabolic syndrome. Journal of Sexual Medicine. 2012;9(2):434-441. Go to original source... Go to PubMed...
    19. Mittawae B, El-Nashaar AR, Founda A, Magdy M, Shamloul R. Incidence of erectile dysfunction in 800 hypertensive patients: a multicenter Egyptian national study. Urology. 2006;67(3):575-578. Go to original source... Go to PubMed...
    20. Okeahialam BN, Obeka NC. Sexual dysfunction in female hypertensive. Journal of National Medical Associattion. 2006;98(4):638-640.
    21. Pastor Z, Zámečník L, Chaloupka V, Červený R, Hollý M, Čechurová D. Doporučený diagnostický a léčebný postup pro všeobecné praktické lékaře. Nadační fond praktik; 2008 [cited 2014 Aug 12]. Available from: http://www.svl.cz/files/files/Doporucene-postupy-20082012/erektilni-dysfunkce.pdf/ (in Czech)
    22. Sovová E, Řehová J. Kardiologie pro obor ošetřovatelství. 1. vyd. Praha: Grada; 2004. (in Czech)
    23. Steinke EE. Intimaci need and chronic illnes: Strategies for sexual counseling and self-management. Journal of Gerontological nursing. 2005;31(5):40-50. Go to original source... Go to PubMed...
    24. Steggall MJ. Erectile dysfunction: fysiology, cause and patient management. Nursing standard. 2007;21(43):49-56. Go to original source...
    25. Šrámková T. Poruchy sexuality u somaticky nemocných a jejich léčba. 1. vyd. Praha: Grada Publishing; 2013. (in Czech)
    26. Šrenkel J. Sexuální výchova a protokol sexuality v domovech sociálních služeb. In: Mitlohner M, Prouzová Z, editors. 21.
    27. Celostátní kongres k sexuální výchově v České Republice, Pardubice, 2013, Sborník referátů. Ostrava: CAT; 2013. s. 210-221. (in Czech)
    28. Vique J et al. Zdravý sexuální život. Čestlice: Rebo Production; 2006. (in Czech)
    29. Yang L, Yu J, Ma R, Zhao F, Lin X, Liu P, Hu H, Bai F. The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial. Cardiology. 2013;125(4):235- 241. Go to original source... Go to PubMed...

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